Probably a bad idea to let the player character know you're the guy responsible for coding the universe.
And of course this comic references the oh-so-handy Missingno.-related glitches in Gen I. I know glitch exploitation in video games is a controversial issue, but I personally don't see anything wrong with it as long as you're not using it to gain an unfair competitive advantage. For example, once you max out effort values, there's no real difference between a Pokémon you trained to level 100, a Pokémon you got to level 100 via Rare Candies and EXP Candies you found naturally in the game, and a Pokémon you got to level 100 via Rare Candies and EXP Candies you obtained through glitches.
Using glitches or cheats to give a Pokémon an impossible moveset or unobtainably high stats, and then using that Pokémon in a tournament, would definitely be cheating and there's never an excuse for that. But if you're just battling with your friends, and you tell them how you got your impossible Pokémon so they can do it too, that's a completely different context where everybody benefits. (When my niece played Pokémon Red, I told her about the Missingno. glitches and it was driving her crazy having to wait to reach Cinnabar Island to use them. Why is life so hard.)
On the other hand, I was never fond of devices like the GameShark that allowed you to essentially modify a game's code freely to do whatever you wanted the game to do. That kind of thing pretty much destroys the entire purpose of playing a video game and robs players of the satisfaction of working hard for anything. If you input the right codes, sure you can make a save file where Red starts off in Pallet Town with 6 level 100 Mewtwo, a full Pokédex, and all 8 Gym Badges... but what's the point? Bragging rights? (Pro tip to 10-year-old boys, it's not very impressive if you brag about achievements you didn't actually earn.) Reinforcing the idea that if you throw enough money at anything you can achieve it with minimal effort but still gain the benefits attained from working for it? (If you think that, you're going to get a rude awakening when adulthood hits.)
I mean, yeah, stuff like the GameShark can be an entertaining diversion if you've played a video game to death and just want to mess with the code, but I'm not on board with the idea of using cheat devices as a shortcut to achieving something that's supposed to take time and effort. It benefits no one, least of all the person using the cheat device and sinking further into the depths of being an obnoxiously entitled human being whom nobody wants to be around.
... Whoa, that was a bit of a rant. I'm getting cantankerous in my old age, I guess.